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Nordic公司于1934年以生产药物和化合物成立于荷兰,逐渐转向以生产免疫学和抗血清为主营业务。公司与荷兰卫生组织研究院在应用科学研究合作,研究出一系列独特的人、小鼠、猴和大鼠免疫球蛋白及其亚基的抗血清。

Nordic Immunological Laboratories offer a range of immunologic reagents including:

·                         precipitating polyclonal antisera

·                         polyclonal reagents for immunofixation

·                         cytochemical grade purified IgG(7S) fractions of poly­clonal antisera and purified polyclonal antibodies

·                         monoclonal antibodies, fluorescent, biotin and peroxidase immuno­conjugates

·                         polyclonal fluorescent, biotin and peroxidase immunoconjugates

·                         normal sera, milk and purified proteins

Contrary to still widely held opinion, immuno­logic reagents are usually not general purpose reagents for universal use. Different tech­niques and even different modifi­cations or arrangements of an otherwise established method frequently result in different require­ments for the reagents. These differences are not only associated with the properties of the antibody, but also with the characte­ristics of other humoral or cellular components under the conditions of the test system.

Inter-species cross-reactivity is a normal feature of antibodies to animal proteins, since homologous proteins of different species frequently share antigenic determinants.

Although cross-reactivity of polyclonal antisera can in principle be removed by cross-adsorption, it is frequently difficult to achieve this even for a single species and it may result in a significant loss of required antibody activity. On the other hand, it can be used to advantage if a comparable primary antiserum is not available and the reaction pattern is correctly recognized and understood.

For use in mixed mouse/human test systems Nordic makes available 7S fractions and immunoconjugates from a goat antiserum to all known mouse Ig-isotypes, cross-adsorbed to minimize reactivity with any component of the human Ig system. The same series of products also exist for the mixed rat/human system.

Antisera, labelled or unlabelled, may be offered in different forms:

·                         whole unfractionated serum

·                         IgG fraction (7S)

·                         isolated monoclonal antibodies (MAb)

·                         immuno­affinity isolated antibodies (PAb)

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