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Allergen: |
nDer p 2 (Dermatophagoides pteronyssinus allergen 2) |
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Unit: |
250μg |
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Source: |
D.pteronyssinus culture medium |
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Mol. Wt: |
14 kD |
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Purification: |
From mite culture by multi-step chromatographic purification.
Purity on silver stained SDS-PAGE >95%.
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Concentration: |
See package insert. Based on Advanced Protein Assay.
(Cytoskeleton Inc., Denver, CO) |
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Formulation: |
Preservative and carrier-free in sterile, endotoxin-free,
phosphate buffered saline, pH 7.4
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Storage: |
Store at -20oC |
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Notes: |
A LoTox? product, Endotoxin ≤ 0.03EU/μg. |
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PDB: |
1KTJ X-ray crystal structure; 1A9V NMR structure |
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Product Resources: |
LoTox? Natural Der p 2 Certificate of Analysis |
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Related products: |
NA-DP2 -- Natural Der p 2
RE-DP2A -- Recombinant Der p 2.0101 (E.coli)
RP-DP2C -- Recombinant Der p 2.0103 (Pichia pastoris)
EL-D2 -- Mite Group 2 ELISA
ST-UAS -- Universal Allergen Standard
MA-1D8-1 -- 1D8 anti Group 2
MA-DPX-1 -- DpX anti Group 2
BI-1D8-1 -- Biotinylated 1D8 anti Group2
BI-7A1-1 -- Biotinylated 7A1 anti Group 2
CH-1 -- Mouse anti-Der p 2/human IgE (2B12-IgE)
CH-2 -- Mouse anti-Der p 2/human IgG1 (2B12-IgG1)
CH-3 -- Mouse anti-Der p 2/human IgG4 (2B12-IgG4) |
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For Research Use Only: Not for Diagnostic or Therapeutic Use |
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References: |
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Heyman PW, Chapman MD, Fox J, Aalberse, RC, PlattsMills, TAE. Antigenic and structural analysis of the Group II allergens (Derp II and Der f II) from house dust mites (Dermatophagoides sp). J Allergy Clin Immunology 1989;83:1055-67.
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Mueller GA, Smith AM, Williams DC Jr., Hakkaart GAJ, Aalberse RC, Chapman MD, Rule, GS, Benjmin DC. Expression and secondary structure determination by NMR methods of the major house dust mite allergen Der p 2. J Biol Chem 1997;272:26893-8.
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Smith AM, Benjamin DC, Hozic N, Derewenda U, Smith WA, Thomas WR, Gafvelin G, van Hage-Hamsten M, Chapman MD. The molecular basis of antigenic cross-reactivity between the group 2 mite allergens. J Allergy Clin Immunol 2001;107:977-84.
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Trompette A, Divanovic S, Visintin A, Blanchard C, Hegde RS, Madan R, Thorne PS, Wills-Karp M, Gioannini TL, Weiss JP, Karp CL. Allergenicity resulting from functional mimicry of a Toll-like receptor complex protein. Nature 2008, Dec. 7.
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