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SB431542

产品编号:Asc-163
产品规格:1mg/5mg/10mg
价  格:999.00/1277.00/2276.00
供 应 商:Ascent
库  存:常年库存
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SB431542      ALK inhibitor

Purity: >99%

Biological Description

Potent and selective inhibitor of Activin like Kinase. Inhibits ALK 4, 5 (IC50 = 94 nM), and 7.

Useful References

Inman et al (2002) SB-431542 is a potent and specific inhibitor of transforming growth factor-beta superfamily type I activin receptor-like kinase (ALK) receptors ALK4, ALK5, and ALK7. Mol Pharmacol. 62:65-74 abstract

Halder et al (2005) A specific inhibitor of TGF-beta receptor kinase, SB-431542, as a potent antitumor agent for human cancers. Neoplasia 7:509-21 abstract

Laping et al (2002) Inhibition of transforming growth factor (TGF)-beta1-induced extracellular matrix with a novel inhibitor of the TGF-beta type I receptor kinase activity: SB-431542. Mol Pharmacol.62:58-64 abstract

Chemical Information

4-[4-(3,4-Methylenedioxyphenyl)-5-(2-pyridyl)-1H-imidazol-2-yl]benzamide


  • Desiccate at RT
  • MW 384.39
  • Soluble in DMSO to 100mM and in ethanol to 10mM
  • C22H16N4O3
  • 301836-41-9

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